SYNGENE Career Opportunities: Research Investigator-Drug Transporter Research Apply Now
Designation: Research Investigator/ Principal Investigator
Job Location: Bangalore
Department: Discovery Biology
About Syngene
Incorporated in 1993, Syngene International Ltd. is an
innovation-focused global discovery, development and manufacturing organization
providing integrated scientific services to the pharmaceutical, biotechnology,
nutrition, animal health, consumer goods and specialty chemical industries
around the world. Syngene’ s clientele includes world leaders such as
Bristol-Myers Squibb, Baxter, Amgen, GSK, Merck KGaA and Herbalife. Its
innovative culture is driven by the passion of its 4240- strong team of
scientists who work with clients from around the world to solve their
scientific problems, improve R&D productivity, speed up time to market and
lower the cost of innovation.
Job Purpose
Scientific leadership role to establish Drug Transporter Protein
Sciences Research Group
Interact with cross functional scientific teams and external
collaborators and remain as a subject matter expert in the field of transporter
protein sciences
Identification of likely transporter interactions of lead
compounds and provide mitigation strategy
Build capability to understand physchem properties that are
related to the transporter protein liabilities in drug discovery programs
Preparation of IND packages to support investigative studies that
are part of regulatory submissions
Key Responsibilities:
Develop tools and reagents to investigate role of drug
transporters in the disposition of small molecules
Integration of study results obtained from suspension and
plateable hepatocytes to assess the contribution of uptake clearance mechanism
in the overall disposition
Seamless coordination with
in vivo DMPK group to design in vivo studies for integration of in vitro
findings
Design and execute In vitro uptake assays in suspension, plateable
hepatocytes and in the transporter transfected cell lines
Integration of mechanistic ADME study results with transporter
protein functionally and provide directions for the progression of molecules
Preparation of SOP’s and EOPs
Reporting of the executed studies with high level of data
integrity
Reporting of study results clearly in the cross functional
scientific meetings
Follow environment, health, and safety (EHS) requirements at all
times in the workplace ensuring individual and lab/plant safety
Ensure environment, health, and safety (EHS) measures are imparted
via training and adhered within the team
Educational
Qualification:
A Ph.D. in pharmaceutical sciences or biological science. Five or
more years of Post-doctoral and/or Industrial experience in transporter protein
sciences research.
Technical/functional Skills:
Comprehensive understanding of in vitro ADME assays and technical
expertise in trouble shooting the assays
Several years of experience in conducting In vitro cell based
assays using suspension and plateable hepatocytes and transporter (OATPs, OAT,
OCT and MATES) transfected cell lines
In depth understanding of biochemical and aspects of enzyme
kinetics is highly desirable related to the transporter proteins
Reasonable understanding of PBPK aspects and DDI risk assessment
related to transporter proteins are essential
Demonstrated cross functional leadership capabilities
Experience with automation is desirable
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